학력

서울대학교 이학박사 (치의학_구강악안면 감염-면역학 전공)

조선대학교 이학사 (생물과학부)

경력사항

서울대학교 치학연구소 연구부교수/교수

서울대학교 BK21플러스 치의학생명과학사업단 BK조교수/부교수

서울대학교 치학연구소 선임연구원

서울대학교 치과대학 BK21사업단 BK전임강사

논문

*61. (co-frist) Jiseon Kim, Ok-Jin Park, Yeongkag Kwon, Chaeyeon Park, Jueun Lee, Cheol-Heui Yun, Seung Hyun Han (2026.02) Oral delivery of Lactobacillus species peptidoglycans prevents postmenopausal osteoporosis via NOD2 signaling and gut microbiota modulation. Biomedicine & pharmacotherapy 195:118976.

60. Yeonjin Lim, Ok-Jin Park, Chaeyeon Park, Bo-Min Kim, Cheol-Heui Yun, Seung Hyun Han (2026.01.15) Oral intake of postbiotic Lactiplantibacillus plantarum ameliorates postmenopausal osteoporosis similarly to probiotic L. plantarum. Journal of Microbiology and Biotechnology 36:e2510013.

*59. (co-corresponding) Bo-Min Kim, Yeonjin Lim, Somin Park, Jintaek Im, Cheol-Heui Yun, Kee-Yeon Kum, Ok-Jin Park, Seung Hyun Han (2026.01.05) Neisseria bacilliformis is a periodontal pathogen exacerbating periodontitis by induction of nitric oxide. Frontiers in Immunology 16:1735500.

58. Chaeyeon Park, Ok-Jin Park, Yeongkag Kwon, Jueun Lee, Cheol-Heui Yun, Seung Hyun Han (2025.12) Differential regulatory effects of probiotics on bone metabolism by the status of bone health and delivery route. Probiotics and Antimicrobial Proteins 17(6):4911-4921. doi: 10.1007/s12602-024-10441-x.

57. Jeongmin Shin, Dong Hyun Park, Woohyung Jun, Ok-Jin Park, Cheol-Heui Yun, Jintaek Im, Seung Hyun Han (2025.09) Optimization of the purification process for Lactiplantibacillus plantarum lipoteichoic acid with anti-biofilm properties against dental pathogens. Journal of Microbiology and Biotechnology Sep 22:35:e2506045.

*56. Ok-Jin Park, Jiseon Kim, Yeonjin Lim, Chaeyeon Park, Cheol-Heui Yun, Seung Hyun Han (2025.08) The dual roles of peptidoglycans: NOD1 and NOD2 inversely regulate bone metabolism. Experimental and Molecular Medicine 57(8):1837-1846

55. Yoon Ju So, Ok-Jin Park, YeongKag Kwon, Jintaek Im, Dongwook Lee, Sung-Ho Yun, Kun Cho, Cheol-Heui Yun, Seung Hyun Han (2025.06) Bacillus subtilis Induces Human Beta Defensin-2 Through its Lipoproteins in Human Intestinal Epithelial Cells. Probiotics and Antimicrobial Proteins 17(3):1648-1662.

*54. (co-first) Euon Jung Tak, Ok-Jin Park, Jin-Sun Lee, Yeon-Jee Yoo, Hiran Perinpanayagam, Yun-Seok Jeong, Jae-Yun Lee, Jin-Woo Bae, Kee-Yeon Kum, Seung Hyun Han (2025.06) Microbiota associated with caries and apical periodontitis: A next-generation sequencing study. International Endodontic Journal 58(6):890-901.

*53. (co-first) Dong Hyun Park, Euon Jung Tak, Ok-Jin Park, Hiran Perinpanayagam, Yeon-Jee Yoo, Hyo-Jeong Lee, Jin-Woo Bae, Kee-Yeon Kum, Seung Hyun Han (2025.04.02) Association between root canals and gingival sulci microbiota in secondary and persistent endodontic infections. Scientific Reports 15(1):11253.

52. Jintaek Im, Jun Ho Jeon, Dongwook Lee, Jeong Woo Park, Woohyung Jun, Suwon Lim, Ok-Jin Park, Cheol-Heui Yun, Seung Hyun Han (2024.12.06) Muramyl dipeptide potentiates Staphylococcus aureus lipoteichoic acid-induced nitric oxide production via TLR2/NOD2/PAFR signaling pathways. Frontiers in Immunology 15:1451315.

*51. (co-corresponding) Jinsung Park, Yeonjin Lim, Chaeyeon Park, Kee-Yeon Kum, Cheol-Heui Yun, Ok-Jin Park, Seung Hyun Han (2024.11) Heat-killed Lancefieldella rimae induces bone resorption by promoting osteoclast differentiation. Journal of Endodontics 50(11):1593-1601.

50. Ji-Young Yoon, Somin Park, Dongwook Lee, Ok-Jin Park, WooCheol Lee, Seung Hyun Han (2024.09.30) Lipoteichoic acid from Lacticaseibacillus rhamnosus GG as a novel intracanal medicament targeting Enterococcus faecalis biofilm formation. Journal of Microbiology 62(10):897-905.

*49. (co-first) Dong Hyun Park, Ok-Jin Park, Yeon-Jee Yoo, Hiran Perinpanayagam, Eun-Bee Cho, Kwangmin Kim, Junhyung Park, W. Craig Noblett, Kee-Yeon Kum, Seung Hyun Han (2024.07) Microbiota Association and Profiling of Gingival Sulci and Root Canals of Teeth with Primary or Secondary/Persistent Endodontic Infections. Journal of Endodontics 50(8):93-102.

48. Yeongkag Kwon, Jihyun Yang, Ok-Jin Park, Chaeyeon Park, Jiseon Kim, Dong Wook Lee, Cheol-Heui Yun, Seung Hyun Han (2023.10.) Lipoteichoic acid inhibits osteoclast differentiation and bone resorption via interruption of gelsolin‐actin dissociation. Journal of Cellular Physiology 238(10):2425-2439.

*47. Ok-Jin Park, Yeongkag Kwon, Jiseon Kim, Chaeyeon Park, Cheol-Heui Yun, Seung Hyun Han (2023. 06.01) Muramyl dipeptide alleviates estrogen deficiency-induced osteoporosis through canonical Wnt signaling. Journal of Pathology 260(2):137-147.

*46. Ok-Jin Park, Ye-Eun Ha, Ju-Ri Sim, Dongwook Lee, Eun-Hye Lee, Sun-Young Kim, Cheol-Heui Yun, Seung Hyun Han (2023.03.28) Butyrate potentiates Enterococcus faecalis lipoteichoic acid-induced inflammasome activation via histone deacetylase inhibition. Cell Death Discovery 9:107.

45. Jintaek Im, Dongwook Lee, Ok-Jin Park, Sathishkumar Natarajan, Junhyung Park, Cheol-Heui YUN, Seung Hyun Han (2022.12.22) RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus growth inhibition by propionate. Frontiers in Microbiology 13:1063650.

*44. (co-fisrt) Ok-Jin Park, A Reum Kim, Yoon Ju So, Jintaek Im, Hyun Jung Ji, Ki Bum Ahn, Ho Seong Seo, Cheol-Heui Yun, Seung Hyun Han (2021.10.14) Induction of apoptotic cell death by oral streptococci in human periodontal ligament cells. Frontiers in Microbiology 12:738047.

*43. (Co-corresponding) Yeongkag Kwon, Chaeyeon Park, Jueun Lee, Donghyun Park, Sungho Jeong, Cheol heui Yun, OK-Jin Park, Seung Hyun Han (2021.5.28) Regulation of bone cell differentiation and activation by microbe-associated molecular patterns. International Journal of Molecular Sciences 22(11):5805. https://doi.org/10.3390/ijms22115805

*42. (co-first) Ok-Jin Park, Solmin Jung, Taehwan Park, A Reum Kim, Dongwook Lee, Hyun-Jung Ji, Ho Seong Seo, Cheol-Heui Yun, Seung Hyun Han (2020.12). Enhanced biofilm formation of Streptococcus gordonii at its lipoprotein deficiency. Molecular Oral Microbiology 35(6):271-278.

*41. (co-first) Ok-Jin Park, Yeongkag Kwon, Chaeyeon Park, Yoon Ju So, Tae Hwan Park, Sungho Jeong, Jintaek Im, Cheol-Heui Yun, Seung Hyun Han (2020.11.24). Streptococcus gordonii: Pathogenesis and host response to its cell wall components. Microorganisms 8(12):1852. doi:10.3390/microorganisms8121852

40. Jintaek Im, Jung Eun Baik, Dongwook Lee, Ok-Jin Park, Cheol-Heui Yun, Seung Hyun Han (2020.10.02). Bacterial lipoproteins induce BAFF production via TLR2/MyD88/JNK signaling pathways in dendritic cells. Frontiers in Immunology 11:564699 https://doi.org/10.3389/fimmu.2020.564699

*39. (co-first) Ok-Jin Park, Moon-Hee Jeong, Eun-Hye Lee, Mi-Ran Cho, Jae-Hong Hwang, Seungryong Cho, Cheol-Heui Yun, Seung Hyun Han, Sun-Young Kim (2020.08.02). A pilot study of chronological microbiota changes in a rat apical periodontitis model. Microorganisms 8(8):1174,

*38. (co-corresponding) Jintaek Im, Jung Eun Baik, Dongwook Lee, Kee-Yeon Kum, Chel-Heui Yun, Ok-Jin Park, Seung Hyun Han (2020.08). Lipoteichoic acid of Enterococcus faecalis interferes with Porphyromonas gingivalis lipopolysaccharide signaling via IRAK-M upregulation in human periodontal ligament cells. Molecular Oral Microbiology 35(4):146-157

*37. (co-first) JihyunYang, Ok-Jin Park, Jiseon Kim, Yeongkag Kwon, Cheol-Heui Yun, Seung Hyun Han (2019.12). Modulation of macrophage subtypes by IRF5 determines osteoclastogenic potential. Journal of Cellular Physiology 234(12):23033-23042.

36. Jihyun Yang, Ok-Jin Park, Jiseon Kim, Sora Han, Young Yang, Cheol-Heui Yun, Seung Hyun Han (2019.11.22). Adiponectin deficiency triggers bone loss by up-regulation of osteoclastogenesis and down-regulation of osteoblastogenesis. Frontiers in Endocrinology 10:815 https://doi.org/10.3389/fendo.2019.00815

*35. (co-corresponding) Soyoung Jeong, Yunjae Lee, Cheol-Heui Yun, Ok-Jin Park, Seung Hyun Han (2019.11). Propionate, together with triple antibiotics, inhibits the growth of Enterococci. Journal of Microbiology 57(11):1019-1024.

34. Yeongkag Kwon, Ok-Jin Park, Jiseon Kim, Jae Ho Cho, Cheol-Heui Yun, Seung Hyun Han (2019.07). Cyclic dinucleotides inhibit osteoclast differentiation through STING-mediated interferon-β signaling. Journal of Bone and Mineral Research 34(7):1366-1375.

*33. (co-first) Solmin Jung, Ok-Jin Park, A Reum Kim, Ki Bum Ahn, Dongwook Lee, Cheol-Heui Yun, Seung Hyun Han (2019.04). Lipoteichoic acids of lactobacilli inhibit Enterococcus faecalis biofilm formation and disrupt the preformed biofilm. Journal of Microbiology 57(4):310-315.

32. A Reum Kim, Ki Bum Ahn, Cheol-Heui Yun, Ok-Jin Park, Hiran Perinpanayagam, Kee-Yeon Kum, Seung Hyun Han (2019.03). Lactobacillus plantarum lipoteichoic acid inhibits oral multispecies biofilm. Journal of Endodontics 45(3):310-315. ISSN: 0099-2399

*31. Ok-Jin Park, Jiseon Kim, Hyun Young Kim, Yeongkag Kwon, Cheol-Heui Yun, Seung Hyun Han (2019.01). Streptococcus gordonii induces bone resorption by increasing osteoclast differentiation and reducing osteoblast differentiation. Microbial Pathogenesis 126(1):218-223.

30. KiBum Ahn, Jung Eun Baik, Ok-Jin Park, Cheol-Heui Yun, Seung Hyun Han (2018.02.08). Lactobacillus plantarum lipoteichoic acid inhibits biofilm formation of Streptococcus mutans. PLOS ONE 13(2):e0192694.

*29. (co-first) Ok‐Jin Park, Jiseon Kim, Ki Bum Ahn, Jue Yeon Lee, Yoon-Jeong Park, Kee-Yeon Kum, Cheol-Heui Yun, Seung Hyun Han (2017.12). A 15-amino acid C-terminal peptide of beta-defensin-3 inhibits bone resorption by inhibiting the osteoclast differentiation and disrupting podosome belt formation Journal of Molecular Medicine 95(12):1315-1325.

28. Kyung Whun Kim, Seok-Seong Kang, Sun-Je Woo, Ok-Jin Park, Ki-Bum Ahn, Ki-Duk Song, Hak-Kyo Lee, Cheol-Heui Yun, Seung Hyun Han (2017.09.21). Lipoteichoic acid of probiotic Lactobacillus plantarum attenuates Poly I:C-induced IL-8 production in porcine intestinal epithelial cells. Frontiers in Microbiology Sep 21;8:1827. doi: 10.3389/fmicb.2017.01827. eCollection 2017.

*27. Ok-Jin Park, Jiseon Kim, Jihyun Yang, Cheol-Heui Yun, Seung Hyun Han (2017.07). Muramyl dipeptide, a shared structural motif of peptidoglycans, is a novel inducer of bone formation through induction of Runx2. Journal of Bone and Mineral Research 32(7):1455-1468

*26. (co-first) Jihyun Yang, Ok-Jin Park, Jiseon Kim, Jung Eun Baik, Cheol-Heui Yun, Seung Hyun Han (2016.04). Lipoteichoic acid of Enterococcus faecalis inhibits the differentiation of macrophages into osteoclasts. Journal of Endodontics 42(4):570-574.

25. Sushila Maharjan, Bijay Singh, Tao Jiang, So-Yeon Yoon, Hui-Shan Li, Girak Kim, Min Jeong Gu, Soo Ji Kim, Ok-Jin Park, Seung Hyun Han, Sang-Kee Kang, Cheol-Heui Yun, Yun-Jaie Choi, Chong-Su Cho. (2016.04) Systemic administration of RANKL overcomes the bottleneck of oral vaccine delivery through microfold cells in ileum. Biomaterials 84: 286-300.

24. Jiseon Kim, Jihyun Yang, Ok-Jin Park, Seok-Seong Kang, Cheol-Heui Yun, Seung Hyun Han (2016.04.01). Serum amyloid A inhibits osteoclast differentiation to maintain macrophage function. Journal of Leukocyte Biology 99(4):595-603.

*23. Ok-Jin Park, Jiseon Kim, Jihyun Yang, Cheol-Heui Yun, Seung Hyun Han (2015.09). Enterococcus faecalis inhibits osteoblast differentiation and induces chemokine e-x-p-r-e-s-s-i-o-n. Journal of Endodontics 41(9):1480-1485.

*22. Ok-Jin Park, Min-Kyung Cho, Cheol-Heui Yun, Seung Hyun Han (2015.09). Lipopolysaccharide of Aggregatibacter actinomycetemcomitans induces the e-x-p-r-e-s-s-i-o-n of chemokines MCP-1, MIP-1α, and IP-10 via similar but distinct signaling pathways in murine macrophages Immunobiology 220(9): 1067-1074.

21. Seok-Seong Kang, Su-Young Noh, Ok-Jin Park, Cheol-Heui Yun, Seung Hyun Han (2015.09). Staphylococcus aureus induces IL-8 e-x-p-r-e-s-s-i-o-n through its lipoproteins in the human intestinal epithelial cell Caco-2. Cytokine 75(1): 174-180.

*20. Ok-Jin Park, Hana Yi, Jun Ho Jeon, Seok-Seong Kang, Ki-Tae Koo, Kee-Yeon Kum, Jongsik Chun, Cheol-Heui Yun, Seung Hyun Han (2015.07.01). Pyrosequencing analysis of subgingival microbiota in distinct periodontal conditions. Journal of Dental Research 94(7): 921-927.

19. Jintaek Im, Jung Eun Baik, Kyung Whun Kim, Seok-Seong Kang, Jun Ho Jeon, Ok-Jin Park, Hyun Young Kim, Kee-Yeon Kum, Cheol-Heui Yun, Seung Hyun Han (2015.08.01). Enterococcus faecalis lipoteichoic acid suppresses Aggregatibacter actinomycetemcomitans lipopolysaccharide-induced IL-8 e-x-p-r-e-s-s-i-o-n in human periodontal ligament cells. International Immunology 27(8): 381-391.

*18. Ok-Jin Park, Jihyun Yang, Jiseon Kim, Cheol-Heui Yun, Seung Hyun Han (2015.03). Enterococcus faecalis attenuates the differentiation of macrophages into osteoclasts. Journal of Endodontics 41(5):658-662.

17. Ki Bum Ahn, Seok-Seong Kang, Ok-Jin Park, Tae-Il Kim (2014.09). Irradiation by gallium-aluminum-aresenate diode enhances the induction of nitric oxide by Porphyromonas gingivalis in RAW 264.7 cells. Journal of Periodontology 85(9): 1259-1265.

16. Ki Bum Ahn, Jun Ho Jeon, Jung Eun Baik, Ok-Jin Park, Seok-Seong Kang, Cheol-Heui Yun, Jong-Hwan Park, Seung Hyun Han (2014.02). Muramyl dipeptide potentiates the ability of staphylococcal lipoteichoic acid to induce cyclooxygenase-2 e-x-p-r-e-s-s-i-o-n in murine macrophages. Microbes and Infection 16(2): 153-160

*15. Ok-Jin Park, Ji Young Han, Jung Eun Baik, Jun Ho Jeon, Seok-Seong Kang, Cheol-Heui Yun, Jong-Won Oh, Seung Hyun Han (2013.12). Lipoteichoic acid of Enterococcus faecalis induces the e-x-p-r-e-s-s-i-o-n of chemokines via TLR2 and PAFR signaling pathways. Journal of Leukocyte Biology 94(6): 1275-1284

14. Jiseon Kim, Jihyun Yang, Ok-Jin Park, Seok-Seong Kang, Woo-Shin Kim, Kenji Kurokawa, Cheol-Heui Yun, Hong-Hee Kim, Bok Luel Lee, Seung Hyun Han (2013.11). Lipoproteins are an important bacterial component responsible for bone destruction through the induction of osteoclast differentiation and activation. Journal of Bone and Mineral Research 28(11):2381-2391

13. Jung Eun Baik, Sun Woong Hong, Seulggie Choi, Jun Ho Jeon, Ok-Jin Park, Kun Cho, Deog-Gyu Seo, Kee-Yeon Kum, Cheol-Heui Yun, Seung Hyun Han (2013.04). Alpha-amylase is a human salivary protein with affinity to lipopolysaccharide of Aggregatibacter actinomycetemcomitans. Molecular Oral Microbiology 28(2):142-153

12. Seok-Seong Kang, Hye Jin Kim, Mi Seon Jang, Sunjin Moon, Sang In Lee, Jun Ho Jeon, Jung Eun Baik, Ok-Jin Park, Young Min Son, Gi Rak Kim, Donghyun Joo, Heebal Kim, Jae Yong Han, Cheol-Heui Yun, Seung Hyun Han (2012.05). Gene e-x-p-r-e-s-s-i-o-n profile of human peripheral blood mononuclear cells induced by Staphylococcus aureus lipoteichoic acid. International Immunopharmacology 13:454–460.

11. Jounghyen Park, Ok-Jin Park, Won-Joon Yoon, Hyun-Jung Kim, Kang-young Choi, Tae-Joon Cho, Hyun-Mo (2012.02). Functional characterization of a novel FGFR2 mutation, E731K, in craniosynostosis. Journal of Cellular Biochemistry 113(2):257-64.

10. Jun Ho Jeon, Sun Kyung Kim, Jintaek Im, Ki Bum Ahn, Jung Eun Baik, Ok-Jin Park, Cheol-Heui Yun, Seung Hyun Han (2011.02). Trp-P-1, a carcinogenic heterocyclic amine, inhibits lipopolysaccharide-induced maturation and activation of human dendritic cells. Cancer Letters 1;301(1):63-74.

*9. Ok-Jin Park, Hyun-Jung Kim, Kyung-Mi Woo, Jeong-Hwa Back, Hyun-Mo Ryoo (2010.02). FGF2-activated ERK MAP kinase enhances Runx2 acetylation and stabilization. Journal of Biological Chemistry 285(6): 3568-3574.

*8. Ok-Jin Park, Seung-Yun Shin, Youngnim Choi, Myung-Hyun Kim, Chong-Pyoung Chung, Young Ku, Kack-Kyun Kim (2008.07). The association of osteoprotegerin gene polymorphisms with periodontitis. Oral Diseases 14(5):440-4.

7. Jihyun Yang, Ok-Jin Park, Yeon Ju Lee, Hong-Moon Jung, Kyung Mi Woo, Youngnim Choi (2008.06). The 4-1BB ligand and 4-1BB expressed on osteoclast precursors enhance RANKL-induced osteoclastogenesis via bi-directional signaling. European Journal of Immunology 38(6):1598-609.

6. Hyewon Park, Ok-Jin Park, Jieun Shin, Youngnim Choi (2005.12). Receptor activator of NF-kappaB ligand enhances the activity of macrophages as antigen presenting cells. Experimental & Molecular Medicine 31;37(6):524-532.

5. Hyewon Park, Youn-Kwan Jung, Ok-Jin Park, Yeon Ju Lee, Je-Yong Choi, Youngnim Choi (2005.12). Interaction of Fas ligand and Fas expressed on osteoclast precursors increases osteoclastogenesis. Journal of Immunology 1;175(11):7193-201.

*4. Ok-Jin Park, Kyoung-Man Min, Son-Jin Choe, Bong-Kyu Choi, Kack-Kyun Kim (2004.02). Use of insertion sequence element IS1126 in a genotyping and transmission study of Porphyromonas gingivalis. Journal of Clinical Microbiology 42(2):535-541.

3. Seung-Yun Shin, Kyoung-Hwa Kim, Ok-Jin Park, Yong-Moo Lee, In-Chul Rhyu, Kack-Kyun Kim, Young Ku, Hiromasa Yoshie, Soo-Boo Han, Chong-Pyoung Chung (2004.12). 한국인 치주질환환자에서 Fc-gamma receptor유전자다형성 연구. Journal of Periodontal and Implant Science 3(34): 671-681.

2. Seung-Yun Shin, Kyoung-Hwa Kim, Ok-Jin Park, Kack-Kyun Kim, Young Ku, Hiromasa Yoshie, Chong-Pyoung Chung (2003.12). 치주적으로 건강한 한국인에서 IL-1beta유전자다형성 연구. Journal of Periodontal and Implant Science 4(33): 739-746.

1. Seung-Yun Shin, Kyoung-Hwa Kim, Ok-Jin Park, Kack-Kyun Kim, Chong-Pyoung Chung, Hiromasa Yoshie, Young Ku (2003.12). 치주적으로 건강한 한국인에서 Fc-gamma receptor유전자다형성 연구. Journal of Periodontal and Implant Science 4(33): 747-753.

학회활동

- 한국미생물학회 (The Microbiological Society of Korea)

- 대한면역학회 (The Korean Association of Immunologists)

- 대한골대사학회 (Korean Society for Bone and Mineral Research)

- 미국골대사학회 (The American Society for Bone and Mineral Research)